Part of the unified remote on-demand sequence-retrieval work (PR #268): byte-range get_substring, streaming stream_sequence, and whole-seq load_sequence across all bindings, plus md5 resolution in get_substring and zero-length-range consistency. Additive, no breaking changes.

Part of the unified remote on-demand sequence-retrieval work (PR #268): byte-range get_substring, streaming stream_sequence, and whole-seq load_sequence across all bindings, plus md5 resolution in get_substring and zero-length-range consistency. Additive, no breaking changes.

Part of the unified remote on-demand sequence-retrieval work (PR #268): byte-range get_substring, streaming stream_sequence, and whole-seq load_sequence across all bindings, plus md5 resolution in get_substring and zero-length-range consistency. Additive, no breaking changes.

Part of the unified remote on-demand sequence-retrieval work (PR #268): byte-range get_substring, streaming stream_sequence, and whole-seq load_sequence across all bindings, plus md5 resolution in get_substring and zero-length-range consistency. Additive, no breaking changes.

Part of the unified remote on-demand sequence-retrieval work (PR #268). Node no longer auto-downloads whole chromosomes: get_substring is a lean byte-range read; streamSequence and loadSequence/loadAllSequences are exposed. Platform packages and optionalDependencies synced to 0.7.1.

Changelog

0.9.0 - 2026-06-12

The gtars 0.9.0 release. Highlights:

• New gtars-vrs crate: GA4GH VRS allele identifiers from VCF/HGVS, with an
  HGVS parser/AST, allele normalization, and transcript-anchored mapping.
• New Node.js bindings (gtars-node) and R bindings (gtars-r).
• Major gtars-refget overhaul: on-disk sequence store plus a new binary
  transcript store and coordinate mapper.
• gtars-genomicdist: binary FASTA (.fab) genome format with zero-copy
  mmap access; new stranded region-set operations.
• New BAM QC tooling in gtars-uniwig; overlap-engine rewrite in
  gtars-overlaprs; expanded WASM and Python bindings.
• A batch of correctness-audit fixes across VRS, refget, bamqc, and the
  Python HGVS AST.

See the pull request and per-crate changelogs for full details.

What's Changed

• working PR for genomic distributions port by @sanghoonio in #231
• add streaming uniwig alongside current batch parallel implementation by @nsheff in #236
• Refgetstore updates by @nsheff in #237
• Expose more gtars functionality via python by @nsheff in #241
• Fix genomicdist bugs by @nsheff in #244
• add gtars-lola crate, support in-memory db in IGD struct by @sanghoonio in #242
• Release gtars v0.8.0 by @nsheff in #240

Full Changelog: v0.7.0...v0.8.0

Release version 0.7.0

Changed:

• Added FAI (FASTA index) computation and metadata storage for efficient sequence access
• Implemented remote-access RefgetStore with lazy-loading and caching capabilities
• Refactored SequenceRecord from struct to enum (Stub vs Full) to support lazy loading
• Enhanced store API with new constructors (on_disk(), in_memory(), load_remote()) and export methods